Systems and Synthetic Biology Lab
PI: Diego di Bernardo
@diegodibi.bsky.social (BlueSky)
Combining Molecular Biology, Computer Science and Biomedical Engineering to combat diseases
Our lab members come from different backgrounds including Biology, Biomedical and Automation Engineering, and Computer Science and rely on state-of-the-art instrumentation and microfluidics platforms to develop innovative technologies to observe, model and manipulate cell behaviour for biomedical and biotechnological applications.
Systems Biology
Our research aims at developing and applying experimental protocols and computational approaches to measure transcriptional responses of cells to perturbations to elucidate mechanisms of genetic diseases and for drug repurposing.
Synthetic Biology
Synthetic Biology aims at rational engineering of living organisms. The overarching goal of the lab is to improve human well-being by engineering mammalian cells for biotechnological and biomedical applications. To do so, we are translating principles of control engineering in synthetic biology to engineer biomoleculer circuits to solve current challenges in the therapy of rare genetic disorders.
The lab has coordinated the H2020 FET OPEN EU project "COSY-BIO" The COSY-BIO Project — Cosy-Bio
NEWS
Just published in Nature Communications: CASwitch - a high-performance inducible gene expression system for biotechnology #synbio
A short Podcast explaining how CASwitch works!
Just Published: A Biomolecular Circuit for Automatic Gene Regulation inMammalian Cells with CRISPR Technology #synbio
A short Podcast explaining how CRISPRaic works!
Just Published: Investigation of dynamic regulation of TFEBnuclear shuttling by microfluidics and quantitative modelling #TFEB
A short Podcast explaining the dynamics of TFEB nuclear shuttling.
Our Lab is supported by:
