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PI: Diego di Bernardo
@diegodibi.bsky.social (BlueSky)
Combining Molecular Biology, Computer Science and Biomedical Engineering to combat diseases
Combining Molecular Biology, Computer Science and Biomedical Engineering to combat diseases
Our lab combines Biology, Biomedical and Automation Engineering, and Computer Science with state-of-the-art approaches to develop innovative technologies to observe, model and program cell behaviour to advance basic and translational research in rare genetic disorders.
Synthetic Biology & AI
Synthetic Biology & AI
Synthetic Biology aims at rational engineering of living organisms. The overarching goal of the lab is to improve human well-being by engineering mammalian cells for biotechnological and biomedical applications. To do so, we are translating principles of control engineering in synthetic biology to engineer biomoleculer circuits to solve current challenges in the therapy of rare genetic disorders. In parallel, we are exploring how to leverage artificial intelligence as a tool to translate designs into DNA sequences.
The lab has coordinated the H2020 FET OPEN EU project "COSY-BIO" The COSY-BIO Project — Cosy-Bio
Systems Biology
Systems Biology
Our research aims at developing and applying experimental protocols and computational approaches to measure transcriptional responses of cells to perturbations to elucidate mechanisms of genetic diseases and for drug repurposing.
NEWS
NEWS
We just released Carbon-X, the first open source model that can read and write DNA and that researchers can talk to in plain English. It was a team effort including my lab, the incredible Hugging Face team and Qiuly Li @Zhongguancun Academy. More details here: Introducing Carbon-X - a Hugging Face Space by HuggingFaceBio
Our lab is now funded by a prestigious ERC Advanced Grant of €2.5 million over five years for the project DIMERCIRCUITS. The goal: to design synthetic genetic circuits that can dynamically, precisely, and reversibly control gene expression — enabling safer and more personalized gene therapies.
We are hiring PostDocs with expertise in Synthetic BIology or Artificial Intelligence in Bio!!! If interested drop an email to Diego di Bernardo (dibernardo_at_tigem_dot_it)
A short Podcast explaining how CRISPRaic works!
Our Lab is supported by:
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